Goal
Conducting clinical trials in pregnant women and multicenter studies allows us to reduce complications in pregnancy.
Projects
The clinical research area works on the following projects
Collaborating organizations
Publications
- Blood parameters in fetuses infected with cytomegalovirus according to the severity of brain damage and trimester of pregnancy at cordocentesis.
Hawkins-Villarreal A, Moreno-Espinosa AL, Eixarch E, Marcos MA, Martinez-Portilla RJ, Salazar L, Garcia-Otero L, Lopez M, Borrell A, Figueras F, Goncé A. J Clin Virol 2019
- Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene.
Palma-Gudiel H, Eixarch E, Crispi F, Morán S, Zannas AS, Fañanás L. Clin Epigenetics 2019
- Characterization of vaginal microbiota in women with preterm labor with intra-amniotic inflammation.
Cobo T, Vergara A, Collado MC, Casals-Pascula C, Herreros E, Bosch J, Sánchez-García AB, López-Parellada R, Ponce J, Gratacós E. Sci Rep 2019
- A systematic review and meta-analysis of randomized controlled trials comparing 17-alpha-hydroxyprogesterone caproate versus placebo for the prevention of recurrent preterm birth.
Fernandez-Macias R, Martinez-Portilla RJ, Cerrillos L, Figueras F, Palacio M. Int J Gynaecol Obstet 2019
- Cervical consistency index and risk of cesarean delivery after induction of labor at term.
Migliorelli F, Rueda C, Angeles MA, Baños N, Posadas DE, Gratacós E, Palacio M. Ultrasound Obstet Gynecol 2018
- Clinical and Sonographic Model to Predict Cesarean Delivery after Induction of Labor at Term.
Migliorelli F, Baños N, Angeles MA, Rueda C, Salazar L, Gratacós E, Palacio M. Fetal Diagn Ther 2018
- Should phenotype of previous preterm birth influence management of women with short cervix in subsequent pregnancy? Comparison of vaginal progesterone and Arabin pessary.
Care A, Muller-Myhsok B, Olearo E, Todros T, Caradeux J, Goya M, Palacio M, Carreras E, Alfirevic Z. Ultrasound Obstet Gynecol 2018
- Follow-Up of Asymptomatic High-Risk Patients with Normal Cervical Length to Predict Recurrence of Preterm Birth.
Caradeux J, Murillo C, Julià C, Escura S, Ferrero S, Cobo T, Gratacós E, Palacio M. Fetal Diagn Ther 2017
- Influence of perinatal inflammation on the neurodevelopmental outcome of premature infants.
Rodríguez-Trujillo A, Ríos J, Ángeles MA, Posadas DE, Murillo C, Rueda C, Botet F, Bosch J, Vergara A, Gratacós E, Palacio M, Cobo T. J Matern Fetal Neonatal Med 2017
- The frequency-following response (FFR) to speech stimuli: A normative dataset in healthy newborns.
Ribas-Prats T, Almeida L, Costa-Faidella J, Plana M, Corral MJ, Gómez-Roig MD, Escera C. Hear Res 2018
- Associations between neural injury markers of intrauterine growth-restricted infants and neurodevelopment at 2 years of age.
Mazarico E, Llurba E, Cabero L, Sánchez O, Valls A, Martín-Ancel A, Cardenas D, Gómez Roig MD. J Matern Fetal Neonatal Med 2018
- Genetic risk assessment of thrombophilia in patients with adverse obstetric outcomes.
Fernández Arias M, Mazarico E, Gonzalez A, Muniesa M, Molinet C, Almeida L, Gómez Roig MD.. PLoS One 2019
- Multicenter prospective clinical study to evaluate children short-term neurodevelopmental outcome in congenital heart disease (children NEURO-HEART): study protocol.
Ribera I, Ruiz A, Sánchez O, Eixarch E, Antolín E, Gómez-Montes E, Pérez-Cruz M, Cruz-Lemini M, Sanz-Cortés M, Arévalo S, Ferrer Q, Vázquez E, Vega L, Dolader P, Montoliu A, Boix H, Simões RV, Masoller N, Sánchez-de-Toledo J, Comas M, Bartha JM, Galindo A, Martínez JM, Gómez-Roig L, Crispi F, Gómez O, Carreras E, Cabero L, Gratacós E, Llurba E. BMC Pediatr 2019
- Diagnostic performance of third-trimester ultrasound for the prediction of late-onset fetal growth restriction: a systematic review and meta-analysis.
Caradeux J, Martinez-Portilla RJ, Peguero A, Sotiriadis A, Figueras F. Am J Obstet Gynecol 2019
- Distinctive patterns of placental lesions in preeclampsia versus fetal growth restriction and their association with fetoplacental Doppler.
Paules C, Youssef L, Rovira C, Crovetto F, Nadal A, Peguero A, Figueras F, Eixarch E, Crispi F, Miranda J, Gratacós E. Ultrasound Obstet Gynecol 2019
- Maternal and perinatal outcomes after elective induction of labor at 39 weeks in uncomplicated singleton pregnancy: a meta-analysis.
Sotiriadis A, Petousis S, Thilaganathan B, Figueras F, Martins WP, Odibo AO, Dinas K, Hyett J. Ultrasound Obstet Gynecol 2018
- ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth.
Salomon LJ, Alfirevic Z, Da Silva Costa F, Deter RL, Figueras F, Ghi T, Glanc P, Khalil A, Lee W, Napolitano R, Papageorghiou A, Sotiradis A, Stirnemann J, Toi A, Yeo G. Ultrasound Obstet Gynecol 2019
- Evaluation of the quality and reliability of middle cerebral artery and umbilical artery Doppler images within an international randomized controlled trial.
Rial-Crestelo M, Morales-Roselló J, Hernández-Andrade E, Prefumo F, Oros D, Caffici D, Sotiriadis A, Zohav E, Cruz-Martinez R, Parra-Cordero M, Lubuski M, Kacerovsky M, Figueras F. Ultrasound Obstet Gynecol 2019
- Performance of middle cerebral artery peak systolic velocity for the prediction of fetal anemia in untransfused and transfused fetuses: a diagnostic test accuracy meta-analysis.
Martinez-Portilla RJ, Lopez-Felix J, Hawkins-Villareal A, Villafan-Bernal JR, Paz Y Miño F, Figueras F, Borrell A. Ultrasound Obstet Gynecol 2019
- Third-trimester uterine-artery Doppler for prediction of adverse outcome in late small-for-gestational age fetuses: systematic review and meta-analysis.
Martinez-Portilla RJ, Caradeux J, Meler E, Lip-Sosa DL, Sotiriadis A, Figueras F. Ultrasound Obstet Gynecol 2019
- Osteocalcin Serum Levels in Gestational Diabetes Mellitus and Their Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis..
Martinez-Portilla RJ, Villafan-Bernal JR, Lip-Sosa DL, Meler E, Clotet J, Serna-Vela FJ, Velazquez-Garcia S, Serrano-Diaz LC, Figueras F. J Diabetes Res 2018
- Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis.
Villafan-Bernal JR, Acevedo-Alba M, Reyes-Pavon R, Diaz-Parra GA, Lip-Sosa DL, Vazquez-Delfin HI, Hernandez-Muñoz M, Bravo-Aguirre DE, Figueras F, Martinez-Portilla RJ. J Diabetes Res 2019
- Unravelling the link among growth restriction, placental disorders, and stillbirth.
Figueras F. Paediatr Perinat Epidemiol 2019
- Association of plasma lactate concentration at admission of severe preeclampsia to maternal complications.
Peguero A, Parra RA, Carrillo SP, Rojas-Suarez J, Figueras F. Pregnancy Hypertens 2019
- Added value of cerebro-placental ratio and uterine artery Doppler at routine third trimester screening as a predictor of SGA and FGR in nonselected pregnancies.
Rial-Crestelo M, Martinez-Portilla RJ, Cancemi A, Caradeux J, Fernandez L, Peguero A, Gratacos E, Figueras F. J Matern Fetal Neonatal Med 2018
- Longitudinal Assessment of Abdominal Circumference versus Estimated Fetal Weight in the Detection of Late Fetal Growth Restriction.
Basuki TR, Caradeux J, Eixarch E, Gratacós E, Figueras F. Fetal Diagn Ther 2018
- Essential variables for reporting research studies on fetal growth restriction - a Delphi consenus.
Khalil A, Gordijn SJ, Beune IM, Wynia K, Ganzevoort W, Figueras F, Kingdom J, Marlow N, Papageorghiou AT, Sebire N, Zeitlin J, Baschat AA; Fetal Growth Restriction Minimum Reporting Set Working Group. Ultrasound Obstet Gynecol 2018
- Added value of chromosomal microarray analysis above conventional karyotyping in stillbirth work-up: a systematic review and meta-analysis. Review.
Martinez-Portilla RJ, Pauta M, Hawkins-Villarreal A, Rial-Crestelo M, Paz Y Miño F, Madrigal I, Figueras F, Borrell A. Ultrasound Obstet Gynecol 2018
- First-trimester and combined first- and second-trimester prediction of small-for-gestational age and fetuses with late growth restriction.
Sotiriadis A, Figueras F, Eleftheriades M, Papaioannou GK, Chorozoglou G, Dinas K, Papantoniou N. Ultrasound Obstet Gynecol 2018
- Nomograms of Fetal Cardiac Dimensions at 18-41 Weeks of Gestation.
García-Otero L, Gómez O, Rodriguez-López M, Torres X, Soveral I, Sepúlveda-Martínez Á, Guirado L, Valenzuela-Alcaraz B, López M, Martínez JM, Gratacós E, Crispi F. Fetal Diagn Ther 2019
- Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling.
Guitart-Mampel M, Juarez-Flores DL, Youssef L, Moren C, Garcia-Otero L, Roca-Agujetas V, Catalan-Garcia M, Gonzalez-Casacuberta I, Tobias E, Milisenda JC, Grau JM, Crispi F, Gratacos E, Cardellach F, Garrabou G. J Cell Mol Med 2019
- Transgenerational transmission of small for gestational age.
Sepúlveda-Martínez Á, Rodríguez-López M, Paz-Y-Miño F, Casu G, Crovetto F, Gratacós E, Crispi F. Ultrasound Obstet Gynecol 2018
- Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction.
Youssef L, Miranda J, Paules C, Garcia-Otero L, Vellvé K, Kalapotharakos G, Sepulveda-Martinez A, Crovetto F, Gomez O, Gratacós E, Crispi F. Am J Obstet Gynecol 2018
- Determination of the steroid profile in alternative matrices by liquid chromatography tandem mass spectrometry.
Gomez-Gomez A, Miranda J, Feixas G, Arranz Betegon A, Crispi F, Gratacós E, Pozo OJ. J Steroid Biochem Mol Biol 2019
- Complement Activation and Thrombotic Microangiopathies.
Palomo M, Blasco M, Molina P, Lozano M, Praga M, Torramade-Moix S, Martinez-Sanchez J, Cid J, Escolar G, Carreras E, Paules C, Crispi F, Quintana LF, Poch E, Rodas L, Goma E, Morelle J, Espinosa M, Morales E, Avila A, Cabello V, Ariceta G, Chocron S, Manrique J, Barros X, Martin N, Huerta A, Fraga-Rodriguez GM, Cao M, Martin M, Romera AM, Moreso F, Manonelles A, Gratacos E, Pereira A, Campistol JM, Diaz-Ricart M. Clin J Am Soc Nephrol 2019
- Natural History of Atherosclerosis and Abdominal Aortic Intima-Media Thickness: Rationale, Evidence, and Best Practice for Detection of Atherosclerosis in the Young.
Skilton MR, Celermajer DS, Cosmi E, Crispi F, Gidding SS, Raitakari OT, Urbina EM. J Clin Med 2019
- Nomograms of Fetal Right Ventricular Fractional Area Change by 2D Echocardiography.
Guirado L, Crispi F, Soveral I, Valenzuela-Alcaraz B, Rodriguez-López M, García-Otero L, Torres X, Sepúlveda-Martínez Á, Escobar-Diaz MC, Martínez JM, Friedberg MK, Gratacós E, Gómez O. Fetal Diagn Ther 2019
- Comparison of 2D versus M-mode echocardiography for assessing fetal myocardial wall thickness.
Sepúlveda-Martínez A, García-Otero L, Soveral I, Guirado L, Valenzuela-Alcaraz B, Torres X, Rodriguez-Lopez M, Gratacos E, Gómez O, Crispi F. J Matern Fetal Neonatal Med 2018
- Premature placental aging in term small-for-gestational-age and fetal-growth-restricted fetuses.
Paules C, Dantas AP, Miranda J, Crovetto F, Eixarch E, Rodriguez-Sureda V, Dominguez C, Casu G, Rovira C, Nadal A, Crispi F, Gratacos E. Ultrasound Obstet Gynecol 2018
- Early cardiac remodeling in aortic coarctation: insights from fetal and neonatal functional and structural assessment.
Soveral I, Crispi F, Walter C, Guirado L, García-Cañadilla P, Cook A, Bonnin A, Dejea H, Rovira-Zurriaga C, Sánchez de Toledo J, Gratacós E, Martínez JM, Bijnens B, Gómez O. Ultrasound Obstet Gynecol 2020
- First-trimester prediction of small-for-gestational age in women at false-positive high and intermediate risk for aneuploidy.
Yarygina TA, Bataeva RS, Benitez L, Figueras . Ultrasound Obstet Gynecol 2020
- Cytogenetic Investigation in 136 Consecutive Stillbirths: Does the Tissue Type Affect the Success Rate of Chromosomal Microarray Analysis and Karyotype?.
Marquès B, Benitez L, Peguero A, Madrigal I, Gómez O, Figueras F, Borrell A. Fetal Diagn Ther 2020
- Intra- and interobserver reproducibility of second trimester ultrasound cervical length measurement in a general population.
Baños N, Burgos-Artizzu XP, Valenzuela-Alcaraz B, Coronado-Gutiérrez D, Perez-Moreno Á, Ponce J, Gratacós E, Palacio M. J Matern Fetal Neonatal Med 2020
- Main Patterns of Fetal Cardiac Remodeling.
Crispi F, Sepúlveda-Martínez Á, Crovetto F, Gómez O, Bijnens B, Gratacós E. Fetal Diagn Ther 2020
- Vaginal metabolome: towards a minimally invasive diagnosis of microbial invasion of the amniotic cavity in women with preterm labor.
Vicente-Muñoz S, Cobo T, Puchades-Carrasco L, Sánchez-García AB, Agustí N, Palacio M, Pineda-Lucena A, Gratacós E. Sci Rep 2020
- Development and validation of a multivariable prediction model of spontaneous preterm delivery and microbial invasion of the amniotic cavity in women with preterm labor.
Cobo T, Aldecoa V, Figueras F, Herranz A, Ferrero S, Izquierdo M, Murillo C, Amoedo R, Rueda C, Bosch J, Martínez-Portilla RJ, Gratacós E, Palacio M. Am J Obstet Gynecol 2020
- Sources of heterogeneity when studying the cardiovascular effects of fetal growth restriction: an overview of the issues.
Rodriguez-Lopez M, Vergara-Sanchez C, Crispi F, Cepeda IL. J Matern Fetal Neonatal Med 2020
- A Spanish-translated clinical algorithm for management of suspected SARS-CoV-2 infection in pregnant women.
Martinez-Portilla RJ, Goncé A, Hawkins-Villarreal A, Figueras F.. Lancet Infect Dis 2020
- Association of central obesity with unique cardiac remodelling in young adults born small for gestational age.
Gabriel Bernardino, Álvaro Sepúlveda-Martínez, Mérida Rodríguez-López, Susanna Prat-González, Carolina Pajuelo, Rosario J Perea, Maria T Caralt, Francesca Crovetto, Miguel A González Ballester, Marta Sitges, Bart Bijnens, Fàtima Crispi. European Society of Cardiology 2023
- Halo sign in fetal cytomegalovirus infection: cerebral imaging abnormalities and postmortem histopathology in cohort of 35 infected fetuses.
Hawkins-Villarreal A, Castillo K, Nadal A, Planas S, Moreno-Espinosa AL, Alarcón A, Rebollo-Polo M, Figueras F, Gratacós E, Eixarch E, Goncé A.. Ultrasound Obstet Gynecol 2023
- Low-dose aspirin use in the first trimester of pregnancy and odds of congenital anomalies: A meta-analysis of randomized controlled trials.
Garza-Galvan ME, Ferrigno AS, Campos-Zamora M, Bain PA, Easter SR, Kim J, Figueras F, Farber MK, Lumbreras-Marquez MI.. Int J Gynaecol Obstet 2023
- Correlation of placental lesions in patients with systemic lupus erythematosus, antiphospholipid syndrome and non-criteria obstetric antiphospholipid syndrome and adverse perinatal outcomes.
Aleida Susana Castellanos Gutierrez, Francesc Figueras, Gerard Espinosa, Lina Youssef, Fàtima Crispi, Marta Santana, Alfons Nadal, Núria Baños. Placenta. 2023
- Fetal neurosonography at 31-35 weeks reveals altered cortical development in pre-eclampsia with and without small-for-gestational-age fetus.
Basso A, Youssef L, Nakaki A, Paules C, Miranda J, Casu G, Salazar L, Gratacos E, Eixarch E, Crispi F, Crovetto F.. Ultrasound Obstet Gynecol 2022
- Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy..
Palomo M, Youssef L, Ramos A, Torramade-Moix S, Belen Moreno-Castaño A, Martinez-Sanchez J, Bonastre L, Pino M, Gomez-Ramirez P, Martin L, Mateos EG, Sanchez P, Fernandez S, Crovetto F, Escolar G, Carreras E, Castro P, Gratacos E, Crispi F, Diaz-Ricart M.. Am J Obstet Gynecol 2022
- Impact of the COVID-19 Pandemic on Maternal Well-Being during Pregnancy.
Rosalia Pascal, Francesca Crovetto, Irene Casas, Lina Youssef, Cristina Trilla, Marta Larroya, Alex Cahuana, David Boada, Maria Foraster, Elisa Llurba, Jordi Sunyer, Fàtima Crispi, Eduard Gratacos, María Dolores Gómez-Roig. J Clin Med 2022
- Lung function in young adults born small for gestational age at term.
Kilian Vellvé, Álvaro Sepúlveda-Martínez, Mérida Rodríguez-López, Francesca Crovetto, Gabriel Bernardino, Felip Burgos, Rosa Faner, Àlvar Agustí, Bart Bijnens, Eduard Gratacós, Fàtima Crispi, Isabel Blanco. Respirology 2022
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